The Mbd4 DNA glycosylase protects mice from inflammation-driven colon cancer and tissue injury
Much of the global cancer burden is associated with longstanding inflammation accompanied by release of DNA-damaging reactive oxygen and nitrogen species. Here, we report that the Mbd4 DNA glycosylase is protective in the azoxymethane/dextran sodium sulfate (AOM/DSS) mouse model of inflammation-driv...
Main Authors: | Yu, Amy Marie, Calvo, Jennifer A., Muthupalani, Sureshkumar, Samson, Leona D |
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Other Authors: | Massachusetts Institute of Technology. Center for Environmental Health Sciences |
Format: | Article |
Language: | en_US |
Published: |
Impact Journals/National Center for Biotechnology Information (U.S.)
2016
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Online Access: | http://hdl.handle.net/1721.1/102633 https://orcid.org/0000-0002-7112-1454 |
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