The schizophrenia risk gene product miR-137 alters presynaptic plasticity

Noncoding variants in the human MIR137 gene locus increase schizophrenia risk with genome-wide significance. However, the functional consequence of these risk alleles is unknown. Here we examined induced human neurons harboring the minor alleles of four disease-associated single nucleotide polymorph...

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Bibliographic Details
Main Authors: Siegert, Sandra, Seo, Jinsoo, Kwon, Ester, Rudenko, Andrii, Cho, Sukhee, Wang, Wenyuan, Flood, Zachary, Martorell, Anthony, Ericsson, Maria, Mungenast, Alison, Tsai, Li-Huei
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Format: Article
Language:en_US
Published: Nature Publishing Group 2016
Online Access:http://hdl.handle.net/1721.1/102680
https://orcid.org/0000-0002-2206-2590
https://orcid.org/0000-0003-1262-0592
https://orcid.org/0000-0001-8635-0877
https://orcid.org/0000-0002-6335-9681