Multiplex Genome Engineering Using CRISPR/Cas Systems
Functional elucidation of causal genetic variants and elements requires precise genome editing technologies. The type II prokaryotic CRISPR (clustered regularly interspaced short palindromic repeats)/Cas adaptive immune system has been shown to facilitate RNA-guided site-specific DNA cleavage. We en...
Main Authors: | Cong, Le, Ran, F. Ann, Cox, David Daniel, Lin, Shuailiang, Barretto, Robert, Habib, Naomi, Hsu, Patrick, Wu, Xuebing, Jiang, Wenyan, Marraffini, Luciano A., Zhang, Feng |
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Other Authors: | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
Format: | Article |
Language: | en_US |
Published: |
American Association for the Advancement of Science (AAAS)
2016
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Online Access: | http://hdl.handle.net/1721.1/102687 https://orcid.org/0000-0003-2782-2509 https://orcid.org/0000-0002-2189-9743 |
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