One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering

One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering

Mice carrying mutations in multiple genes are traditionally generated by sequential recombination in embryonic stem cells and/or time-consuming intercrossing of mice with a single mutation. The CRISPR/Cas system has been adapted as an efficient gene-targeting technology with the potential for multip...

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Bibliographic Details
Main Authors: Wang, Haoyi, Yang, Hui, Shivalila, Chikdu Shakti, Dawlaty, Meelad M., Zhang, Feng, Jaenisch, Rudolf, Cheng, Albert Wu
Other Authors: Massachusetts Institute of Technology. Computational and Systems Biology Program
Format: Article
Language:en_US
Published: Cell Press/Elsevier 2016
Online Access:http://hdl.handle.net/1721.1/102794
https://orcid.org/0000-0003-2782-2509
https://orcid.org/0000-0002-2905-0306

Internet

http://hdl.handle.net/1721.1/102794
https://orcid.org/0000-0003-2782-2509
https://orcid.org/0000-0002-2905-0306

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