Myocardial drug distribution generated from local epicardial application: Potential impact of cardiac capillary perfusion in a swine model using epinephrine

Myocardial drug distribution generated from local epicardial application: Potential impact of cardiac capillary perfusion in a swine model using epinephrine

Prior studies in small mammals have shown that local epicardial application of inotropic compounds drives myocardial contractility without systemic side effects. Myocardial capillary blood flow, however, may be more significant in larger species than in small animals. We hypothesized that bulk perfu...

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Bibliographic Details
Main Authors: Maslov, Mikhail Y., Pezone, Matthew J., Wei, Abraham E., Wakim, Matthew G., Murray, Michael R., Tsukada, Hisashi, Gerogiannis, Iraklis S., Groothuis, Adam R., Lovich, Mark A., Edelman, Elazer R
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Format: Article
Language:en_US
Published: Elsevier 2016
Online Access:http://hdl.handle.net/1721.1/102951
https://orcid.org/0000-0002-7832-7156

Internet

http://hdl.handle.net/1721.1/102951
https://orcid.org/0000-0002-7832-7156

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