Non-Aqueous Suspensions of Antibodies are Much Less Viscous Than Equally Concentrated Aqueous Solutions

Non-Aqueous Suspensions of Antibodies are Much Less Viscous Than Equally Concentrated Aqueous Solutions

Purpose: The aim of this study was to markedly lower the viscosities of highly concentrated protein, in particular antibody, formulations. An effective approach elaborated herein for γ-globulin and a monoclonal antibody is to replace aqueous solutions with equimolar suspensions in neat organic solv...

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Bibliographic Details
Main Authors: Srinivasan, Charudharshini, Weight, Alisha Kessel, Bussemer, Till, Klibanov, Alexander M.
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:English
Published: Springer Science+Business Media 2016
Online Access:http://hdl.handle.net/1721.1/103112
https://orcid.org/0000-0003-3830-714X

Internet

http://hdl.handle.net/1721.1/103112
https://orcid.org/0000-0003-3830-714X

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