Formation of Chromosomal Domains by Loop Extrusion

Formation of Chromosomal Domains by Loop Extrusion

Topologically associating domains (TADs) are fundamental structural and functional building blocks of human interphase chromosomes, yet the mechanisms of TAD formation remain unclear. Here, we propose that loop extrusion underlies TAD formation. In this process, cis-acting loop-extruding factors, li...

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Bibliographic Details
Main Authors: Fudenberg, Geoffrey, Imakaev, Maksim Viktorovich, Lu, Carolyn, Goloborodko, Anton, Abdennur, Nezar Alexander, Mirny, Leonid A.
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Format: Article
Language:en_US
Published: Elsevier 2016
Online Access:http://hdl.handle.net/1721.1/103380
https://orcid.org/0000-0002-0785-5410
https://orcid.org/0000-0001-5905-6517
https://orcid.org/0000-0002-5320-2728
https://orcid.org/0000-0002-2210-8616
https://orcid.org/0000-0001-5814-0864

Internet

http://hdl.handle.net/1721.1/103380
https://orcid.org/0000-0002-0785-5410
https://orcid.org/0000-0001-5905-6517
https://orcid.org/0000-0002-5320-2728
https://orcid.org/0000-0002-2210-8616
https://orcid.org/0000-0001-5814-0864

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