Formation of Chromosomal Domains by Loop Extrusion
Topologically associating domains (TADs) are fundamental structural and functional building blocks of human interphase chromosomes, yet the mechanisms of TAD formation remain unclear. Here, we propose that loop extrusion underlies TAD formation. In this process, cis-acting loop-extruding factors, li...
| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Elsevier
2016
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| Online Access: | http://hdl.handle.net/1721.1/103380 https://orcid.org/0000-0002-0785-5410 https://orcid.org/0000-0001-5905-6517 https://orcid.org/0000-0002-5320-2728 https://orcid.org/0000-0002-2210-8616 https://orcid.org/0000-0001-5814-0864 |