Identification of a Paralog-Specific Notch1 Intracellular Domain Degron

Identification of a Paralog-Specific Notch1 Intracellular Domain Degron

Upon Notch pathway activation, the receptor is cleaved to release the Notch intracellular domain (NICD), which translocates to the nucleus to activate gene transcription. Using Xenopus egg extracts, we have identified a Notch1-specific destruction signal (N1-Box). We show that mutations in the N1-Bo...

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Bibliographic Details
Main Authors: Broadus, Matthew R., Chen, Tony W., Neitzel, Leif R., Ng, Victoria H., Jodoin, Jeanne, Lee, Laura A., Salic, Adrian, Robbins, David J., Capobianco, Anthony J., Patton, James G., Huppert, Stacey S., Lee, Ethan
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Elsevier 2016
Online Access:http://hdl.handle.net/1721.1/103756
https://orcid.org/0000-0002-5840-6260

Internet

http://hdl.handle.net/1721.1/103756
https://orcid.org/0000-0002-5840-6260

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