Determination of Cellular Processing Rates for a Trastuzumab-Maytansinoid Antibody-Drug Conjugate (ADC) Highlights Key Parameters for ADC Design

Determination of Cellular Processing Rates for a Trastuzumab-Maytansinoid Antibody-Drug Conjugate (ADC) Highlights Key Parameters for ADC Design

Antibody-drug conjugates (ADCs) are a promising class of cancer therapeutics that combine the specificity of antibodies with the cytotoxic effects of payload drugs. A quantitative understanding of how ADCs are processed intracellularly can illustrate which processing steps most influence payload del...

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Bibliographic Details
Main Authors: Kulkarni, Chethana, Betts, Alison M., Wittrup, Karl Dane, Maass, Katie F
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:English
Published: Springer US 2016
Online Access:http://hdl.handle.net/1721.1/103801
https://orcid.org/0000-0003-2398-5896
https://orcid.org/0000-0002-0493-2863

Internet

http://hdl.handle.net/1721.1/103801
https://orcid.org/0000-0003-2398-5896
https://orcid.org/0000-0002-0493-2863

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