Calcium ions tune the zinc-sequestering properties and antimicrobial activity of human S100A12
Human S100A12 is a host-defense protein expressed and released by neutrophils that contributes to innate immunity. Apo S100A12 is a 21 kDa antiparallel homodimer that harbors two Ca(II)-binding EF-hand domains per subunit and exhibits two His3Asp motifs for chelating transition metal ions at the hom...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Royal Society of Chemistry
2016
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| Online Access: | http://hdl.handle.net/1721.1/103879 https://orcid.org/0000-0002-6153-8803 https://orcid.org/0000-0002-1733-9874 https://orcid.org/0000-0001-9179-7972 |