Isogenic Human iPSC Parkinson’s Model Shows Nitrosative Stress-Induced Dysfunction in MEF2-PGC1α Transcription

Isogenic Human iPSC Parkinson’s Model Shows Nitrosative Stress-Induced Dysfunction in MEF2-PGC1α Transcription

Parkinson’s disease (PD) is characterized by loss of A9 dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). An association has been reported between PD and exposure to mitochondrial toxins, including environmental pesticides paraquat, maneb, and rotenone. Here, using a robust, pa...

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Bibliographic Details
Main Authors: Ryan, Scott D., Dolatabadi, Nima, Chan, Shing Fai, Zhang, Xiaofei, Akhtar, Mohd Waseem, Parker, James, Soldner, Frank, Sunico, Carmen R., Nagar, Saumya, Talantova, Maria, Lopez, Kevin, Nutter, Anthony, Shan, Bing, Molokanova, Elena, Zhang, Yaoyang, Han, Xuemei, Nakamura, Tomohiro, Masliah, Eliezer, Yates, John R., Nakanishi, Nobuki, Andreyev, Aleksander Y., Okamoto, Shu-ichi, Jaenisch, Rudolf, Ambasudhan, Rajesh, Lipton, Stuart A., Lee, Brian, 1975-
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Elsevier 2016
Online Access:http://hdl.handle.net/1721.1/103881

Internet

http://hdl.handle.net/1721.1/103881

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