Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes

Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes

Master transcription factors Oct4, Sox2, and Nanog bind enhancer elements and recruit Mediator to activate much of the gene expression program of pluripotent embryonic stem cells (ESCs). We report here that the ESC master transcription factors form unusual enhancer domains at most genes that control...

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Bibliographic Details
Main Authors: Whyte, Warren A., Orlando, David A., Hnisz, Denes, Abraham, Brian J., Lin, Charles Y., Kagey, Michael H., Rahl, Peter B., Lee, Tong Ihn, Young, Richard A., Young, Richard A.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Elsevier 2016
Online Access:http://hdl.handle.net/1721.1/103896
https://orcid.org/0000-0001-8855-8647

Internet

http://hdl.handle.net/1721.1/103896
https://orcid.org/0000-0001-8855-8647

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