Pyruvate as a Pivot Point for Oncogene-Induced Senescence
Regulation of pyruvate fate is an important determinant of anabolic versus catabolic metabolism. A new report in the journal Nature by Kaplon et al. suggests that driving pyruvate oxidation can thwart tumor growth in BRAF-driven melanoma by inducing oncogene-induced senescence, a finding that might...
| Main Authors: | , |
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| Format: | Article |
| Language: | en_US |
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Elsevier
2016
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| Online Access: | http://hdl.handle.net/1721.1/103898 https://orcid.org/0000-0002-8956-5117 https://orcid.org/0000-0002-6702-4192 |