Redox activation of metal-based prodrugs as a strategy for drug delivery

This review provides an overview of metal-based anticancer drugs and drug candidates. In particular, we focus on metal complexes that can be activated in the reducing environment of cancer cells, thus serving as prodrugs. There are many reports of Pt and Ru complexes as redox-activatable drug candid...

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Bibliographic Details
Main Authors: Graf, Nora, Lippard, Stephen J.
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Language:en_US
Published: 2016
Online Access:http://hdl.handle.net/1721.1/103939
https://orcid.org/0000-0002-2693-4982