Catalytic Z-Selective Cross-Metathesis in Complex Molecule Synthesis: A Convergent Stereoselective Route to Disorazole C[subscript 1]

Catalytic Z-Selective Cross-Metathesis in Complex Molecule Synthesis: A Convergent Stereoselective Route to Disorazole C[subscript 1]

A convergent diastereo- and enantioselective total synthesis of anticancer and antifungal macrocyclic natural product disorazole C1 is reported. The central feature of the successful route is the application of catalytic Z-selective cross-metathesis (CM). Specifically, we illustrate that catalyst-co...

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Bibliographic Details
Main Authors: Speed, Alexander W. H., Mann, Tyler J., O’Brien, Robert V., Schrock, Richard Royce, Hoveyda, Amir H.
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Language:en_US
Published: American Chemical Society (ACS) 2016
Online Access:http://hdl.handle.net/1721.1/103978
https://orcid.org/0000-0001-5827-3552

Internet

http://hdl.handle.net/1721.1/103978
https://orcid.org/0000-0001-5827-3552

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