Nucleotide Binding Preference of the Monofunctional Platinum Anticancer-Agent Phenanthriplatin

Nucleotide Binding Preference of the Monofunctional Platinum Anticancer-Agent Phenanthriplatin

The monofunctional platinum anticancer agent phenanthriplatin generates covalent adducts with the purine bases guanine and adenine. Preferential nucleotide binding was investigated by using a polymerase stop assay and linear DNA amplification with a 163-base pair DNA double helix. Similarly to cispl...

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Bibliographic Details
Main Authors: Riddell, Imogen Anne, Johnstone, Timothy, Park, Ga Young, Lippard, Stephen J.
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Language:en_US
Published: John Wiley & Sons 2016
Online Access:http://hdl.handle.net/1721.1/103993
https://orcid.org/0000-0002-6801-0198
https://orcid.org/0000-0002-2693-4982

Internet

http://hdl.handle.net/1721.1/103993
https://orcid.org/0000-0002-6801-0198
https://orcid.org/0000-0002-2693-4982

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