Distinct Prion Strains Are Defined by Amyloid Core Structure and Chaperone Binding Site Dynamics

Distinct Prion Strains Are Defined by Amyloid Core Structure and Chaperone Binding Site Dynamics

Yeast prions are self-templating protein-based mechanisms of inheritance whose conformational changes lead to the acquisition of diverse new phenotypes. The best studied of these is the prion domain (NM) of Sup35, which forms an amyloid that can adopt several distinct conformations (strains) that pr...

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Bibliographic Details
Main Authors: Frederick, Kendra K., Debelouchina, Galia Tzvetanova, Kayatekin, Can, Dorminy, Tea, Jacavone, Angela, Griffin, Robert Guy, Lindquist, Susan
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Elsevier 2016
Online Access:http://hdl.handle.net/1721.1/104011
https://orcid.org/0000-0003-1589-832X
https://orcid.org/0000-0003-1307-882X

Internet

http://hdl.handle.net/1721.1/104011
https://orcid.org/0000-0003-1589-832X
https://orcid.org/0000-0003-1307-882X

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