Targeting virulence: salmochelin modification tunes the antibacterial activity spectrum of β-lactams for pathogen-selective killing of Escherichia coli

New antibiotics are required to treat bacterial infections and counteract the emergence of antibiotic resistance. Pathogen-specific antibiotics have several advantages over broad-spectrum drugs, which include minimal perturbation to the commensal microbiota. We present a strategy for targeting antib...

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Bibliographic Details
Main Authors: Chairatana, Phoom, Zheng, Tengfei, Nolan, Elizabeth Marie
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Language:en_US
Published: Royal Society of Chemistry 2016
Online Access:http://hdl.handle.net/1721.1/104034
https://orcid.org/0000-0002-6153-8803
https://orcid.org/0000-0002-5356-3638