Targeting virulence: salmochelin modification tunes the antibacterial activity spectrum of β-lactams for pathogen-selective killing of Escherichia coli
New antibiotics are required to treat bacterial infections and counteract the emergence of antibiotic resistance. Pathogen-specific antibiotics have several advantages over broad-spectrum drugs, which include minimal perturbation to the commensal microbiota. We present a strategy for targeting antib...
Main Authors: | Chairatana, Phoom, Zheng, Tengfei, Nolan, Elizabeth Marie |
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Other Authors: | Massachusetts Institute of Technology. Department of Chemistry |
Format: | Article |
Language: | en_US |
Published: |
Royal Society of Chemistry
2016
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Online Access: | http://hdl.handle.net/1721.1/104034 https://orcid.org/0000-0002-6153-8803 https://orcid.org/0000-0002-5356-3638 |
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