Quality score compression improves genotyping accuracy

To the Editor: Most next-generation sequencing (NGS) quality scores are space intensive, redundant and often misleading. In this Correspondence, we recover quality information directly from sequence data using a compression tool named Quartz, rendering such scores redundant and yielding substantial...

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Bibliographic Details
Main Authors: Yu, Yun William, Yorukoglu, Deniz, Peng, Jian, Berger Leighton, Bonnie
Other Authors: Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
Format: Article
Language:en_US
Published: Springer Nature 2016
Online Access:http://hdl.handle.net/1721.1/104079
https://orcid.org/0000-0002-8275-9576
https://orcid.org/0000-0003-2315-0768
https://orcid.org/0000-0002-2724-7228