Experimental design-aided systematic pathway optimization of glucose uptake and deoxyxylulose phosphate pathway for improved amorphadiene production

Artemisinin is a potent antimalarial drug; however, it suffers from unstable and insufficient supply from plant source. Here, we established a novel multivariate-modular approach based on experimental design for systematic pathway optimization that succeeded in improving the production of amorphadie...

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Detalhes bibliográficos
Principais autores: Zhang, Congqiang, Zou, Ruiyang, Chen, Xixian, Stephanopoulos, Gregory, Too, Heng-Phon
Outros Autores: Massachusetts Institute of Technology. Department of Chemical Engineering
Formato: Artigo
Idioma:English
Publicado em: Springer Berlin Heidelberg 2016
Acesso em linha:http://hdl.handle.net/1721.1/104360
https://orcid.org/0000-0001-6909-4568