Loss of Tet Enzymes Compromises Proper Differentiation of Embryonic Stem Cells

Loss of Tet Enzymes Compromises Proper Differentiation of Embryonic Stem Cells

Tet enzymes (Tet1/2/3) convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) and are dynamically expressed during development. Whereas loss of individual Tet enzymes or combined deficiency of Tet1/2 allows for embryogenesis, the effect of complete loss of Tet activity and 5hmC marks in de...

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Bibliographic Details
Main Authors: Dawlaty, Meelad M., Breiling, Achim, Le, Thuc, Barrasa, M. Inmaculada, Raddatz, Günter, Gao, Qing, Powell, Benjamin E., Cheng, Albert W., Faull, Kym F., Lyko, Frank, Jaenisch, Rudolf
Other Authors: Massachusetts Institute of Technology. Computational and Systems Biology Program
Format: Article
Language:en_US
Published: Elsevier 2016
Online Access:http://hdl.handle.net/1721.1/104804

Internet

http://hdl.handle.net/1721.1/104804

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