Brag2 differentially regulates β1- and β3-integrin-dependent adhesion in endothelial cells and is involved in developmental and pathological angiogenesis

Brag2 differentially regulates β1- and β3-integrin-dependent adhesion in endothelial cells and is involved in developmental and pathological angiogenesis

β1-Integrins are essential for angiogenesis. The mechanisms regulating integrin function in endothelial cells (EC) and their contribution to angiogenesis remain elusive. Brag2 is a guanine nucleotide exchange factor for the small Arf-GTPases Arf5 and Arf6. The role of Brag2 in EC and angiogenesis an...

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Bibliographic Details
Main Authors: Manavski, Yosif, Carmona, Guillaume, Bennewitz, Katrin, Tang, Zhongshu, Zhang, Fan, Sakurai, Atsuko, Zeiher, Andreas M., Gutkind, J. Silvio, Li, Xuri, Kroll, Jens, Dimmeler, Stefanie, Chavakis, Emmanouil
Other Authors: Koch Institute for Integrative Cancer Research at MIT
Format: Article
Language:English
Published: Springer-Verlag 2016
Online Access:http://hdl.handle.net/1721.1/104868

Internet

http://hdl.handle.net/1721.1/104868

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