Holes in the Glycan Shield of the Native HIV Envelope Are a Target of Trimer-Elicited Neutralizing Antibodies

Holes in the Glycan Shield of the Native HIV Envelope Are a Target of Trimer-Elicited Neutralizing Antibodies

A major advance in the search for an HIV vaccine has been the development of a near-native Envelope trimer (BG505 SOSIP.664) that can induce robust autologous Tier 2 neutralization. Here, potently neutralizing monoclonal antibodies (nAbs) from rabbits immunized with BG505 SOSIP.664 are shown to reco...

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Bibliographic Details
Main Authors: McCoy, Laura E., van Gils, Marit J., Ozorowski, Gabriel, Messmer, Terrence, Briney, Bryan, Voss, James E., Kulp, Daniel W., Macauley, Matthew S., Sok, Devin, Pauthner, Matthias, Menis, Sergey, Cottrell, Christopher A., Torres, Jonathan L., Hsueh, Jessica, Schief, William R., Wilson, Ian A., Ward, Andrew B., Sanders, Rogier W., Burton, Dennis R.
Other Authors: Ragon Institute of MGH, MIT and Harvard
Format: Article
Language:en_US
Published: Elsevier 2016
Online Access:http://hdl.handle.net/1721.1/104939

Internet

http://hdl.handle.net/1721.1/104939

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