Human calprotectin is an iron-sequestering host-defense protein

Human calprotectin (CP) is a metal-chelating antimicrobial protein of the innate immune response. The current working model states that CP sequesters manganese and zinc from pathogens. We report the discovery that CP chelates iron and deprives bacteria of this essential nutrient. Elemental analysis...

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Bibliographic Details
Main Authors: Zhang, Bo, Krebs, Carsten, Nakashige, Toshiki George, Nolan, Elizabeth Marie
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Language:en_US
Published: Springer Nature 2016
Online Access:http://hdl.handle.net/1721.1/105103
https://orcid.org/0000-0002-6234-8155
https://orcid.org/0000-0002-6153-8803