Human calprotectin is an iron-sequestering host-defense protein

Human calprotectin (CP) is a metal-chelating antimicrobial protein of the innate immune response. The current working model states that CP sequesters manganese and zinc from pathogens. We report the discovery that CP chelates iron and deprives bacteria of this essential nutrient. Elemental analysis...

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Podrobná bibliografie
Hlavní autoři: Zhang, Bo, Krebs, Carsten, Nakashige, Toshiki George, Nolan, Elizabeth Marie
Další autoři: Massachusetts Institute of Technology. Department of Chemistry
Médium: Článek
Jazyk:en_US
Vydáno: Springer Nature 2016
On-line přístup:http://hdl.handle.net/1721.1/105103
https://orcid.org/0000-0002-6234-8155
https://orcid.org/0000-0002-6153-8803