A Fluorinated Ligand Enables Room-Temperature and Regioselective Pd-Catalyzed Fluorination of Aryl Triflates and Bromides

A Fluorinated Ligand Enables Room-Temperature and Regioselective Pd-Catalyzed Fluorination of Aryl Triflates and Bromides

A new biaryl monophosphine ligand (AlPhos, L1) allows for the room-temperature Pd-catalyzed fluorination of a variety of activated (hetero)aryl triflates. Furthermore, aryl triflates and bromides that are prone to give mixtures of regioisomeric aryl fluorides with Pd-catalysis can now be converted t...

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Bibliographic Details
Main Authors: Sather, Aaron C., Lee, Hong Geun, De La Rosa, Valentina Y., Yang, Yang, Mueller, Peter, Buchwald, Stephen Leffler
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Language:en_US
Published: American Chemical Society (ACS) 2016
Online Access:http://hdl.handle.net/1721.1/105162
https://orcid.org/0000-0003-3928-2984
https://orcid.org/0000-0001-8075-1100
https://orcid.org/0000-0003-3875-4775

Internet

http://hdl.handle.net/1721.1/105162
https://orcid.org/0000-0003-3928-2984
https://orcid.org/0000-0001-8075-1100
https://orcid.org/0000-0003-3875-4775

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