Joint Bayesian inference of risk variants and tissue-specific epigenomic enrichments across multiple complex human diseases

Genome wide association studies (GWAS) provide a powerful approach for uncovering disease-associated variants in human, but fine-mapping the causal variants remains a challenge. This is partly remedied by prioritization of disease-associated variants that overlap GWAS-enriched epigenomic annotations...

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Bibliographic Details
Main Authors: Li, Yue, Kellis, Manolis
Other Authors: Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
Format: Article
Language:en_US
Published: Oxford University Press 2016
Online Access:http://hdl.handle.net/1721.1/105218