Joint Bayesian inference of risk variants and tissue-specific epigenomic enrichments across multiple complex human diseases

Genome wide association studies (GWAS) provide a powerful approach for uncovering disease-associated variants in human, but fine-mapping the causal variants remains a challenge. This is partly remedied by prioritization of disease-associated variants that overlap GWAS-enriched epigenomic annotations...

Полное описание

Библиографические подробности
Главные авторы: Li, Yue, Kellis, Manolis
Другие авторы: Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
Формат: Статья
Язык:en_US
Опубликовано: Oxford University Press 2016
Online-ссылка:http://hdl.handle.net/1721.1/105218