Single-Molecule Studies of Origin Licensing Reveal Mechanisms Ensuring Bidirectional Helicase Loading

Single-Molecule Studies of Origin Licensing Reveal Mechanisms Ensuring Bidirectional Helicase Loading

Loading of the ring-shaped Mcm2–7 replicative helicase around DNA licenses eukaryotic origins of replication. During loading, Cdc6, Cdt1, and the origin-recognition complex (ORC) assemble two heterohexameric Mcm2–7 complexes into a head-to-head double hexamer that facilitates bidirectional replicati...

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Bibliographic Details
Main Authors: Friedman, Larry J., Gelles, Jeff, Ticau, Simina, Ivica, Nikola, Bell, Stephen P
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Elsevier 2016
Online Access:http://hdl.handle.net/1721.1/105277
https://orcid.org/0000-0001-9500-7544
https://orcid.org/0000-0002-0124-0087
https://orcid.org/0000-0002-2876-610X

Internet

http://hdl.handle.net/1721.1/105277
https://orcid.org/0000-0001-9500-7544
https://orcid.org/0000-0002-0124-0087
https://orcid.org/0000-0002-2876-610X

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