Significance of the balance between intracellular glutathione and polyethylene glycol for successful release of small interfering RNA from gold nanoparticles

Significance of the balance between intracellular glutathione and polyethylene glycol for successful release of small interfering RNA from gold nanoparticles

The therapeutic promise of small interfering RNAs (siRNAs) for specific gene silencing is dependent on the successful delivery of functional siRNAs to the cytoplasm. Their conjugation to an established delivery platform, such as gold nanoparticles, offers tremendous potential for treating diseases a...

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Bibliographic Details
Main Authors: McCully, Mark, Hernandez, Yulan, Hursthouse, Andrew, Stirling, David, Baptista, Pedro V., de la Fuente, Jesus M., Berry, Catherine C., Osorio De Castro Conde, Joao
Other Authors: Institute for Medical Engineering and Science
Format: Article
Language:English
Published: Tsinghua University Press 2016
Online Access:http://hdl.handle.net/1721.1/105547
https://orcid.org/0000-0001-8422-6792

Internet

http://hdl.handle.net/1721.1/105547
https://orcid.org/0000-0001-8422-6792

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