Nuclear magnetic resonance sensors and methods for chemical sensing in tissue
Thesis: S.M., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2016.
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| Format: | Thesis |
| Language: | eng |
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Massachusetts Institute of Technology
2016
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| Online Access: | http://hdl.handle.net/1721.1/105679 |
| _version_ | 1826208816136454144 |
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| author | Bashyam, Ashvin (Ashvin Reddy) |
| author2 | Michael J. Cima. |
| author_facet | Michael J. Cima. Bashyam, Ashvin (Ashvin Reddy) |
| author_sort | Bashyam, Ashvin (Ashvin Reddy) |
| collection | MIT |
| description | Thesis: S.M., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2016. |
| first_indexed | 2024-09-23T14:12:46Z |
| format | Thesis |
| id | mit-1721.1/105679 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T14:12:46Z |
| publishDate | 2016 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/1056792019-04-11T01:57:04Z Nuclear magnetic resonance sensors and methods for chemical sensing in tissue Bashyam, Ashvin (Ashvin Reddy) Michael J. Cima. Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science. Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science. Electrical Engineering and Computer Science. Thesis: S.M., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2016. Cataloged from PDF version of thesis. Includes bibliographical references (pages 100-107). Rapid, sensitive, and minimally invasive sensing of metabolites, chemicals, and biological molecules within tissue is a largely unsolved problem. Sensing molecular oxygen, pH, and water content is of particular interest as they have been shown to be useful for improving disease diagnosis and treatment monitoring in a diverse range of medical fields including trauma, solid tumor cancers, tissue grafts, wound healing, dehydration, athletic performance, and congestive heart failure. Nuclear magnetic resonance (NMR) offers a non-ionizing, rapid, repeatable, and molecularly sensitive measurement technique for chemical sensing. Existing hardware for highly versatile single sided measurement systems is insufficient for clinical use due to constraints on the size and shape of samples that can be measured, inadequate magnetic field performance, and low sensitivity. This thesis describes the development of a portable, single-sided NMR system for research and clinical use. A magnet assembly based on a linear Halbach array was developed to produce a large, remote, and uniform field. Suitable impedance matching circuitry was designed and constructed to efficiently transmit signals between NMR probes and a radiofrequency spectrometer. This system is suitable for use in NMR measurement within a clinical environment. by Ashvin Bashyam. S.M. 2016-12-05T19:57:43Z 2016-12-05T19:57:43Z 2016 2016 Thesis http://hdl.handle.net/1721.1/105679 964450472 eng M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/7582 107 pages application/pdf Massachusetts Institute of Technology |
| spellingShingle | Electrical Engineering and Computer Science. Bashyam, Ashvin (Ashvin Reddy) Nuclear magnetic resonance sensors and methods for chemical sensing in tissue |
| title | Nuclear magnetic resonance sensors and methods for chemical sensing in tissue |
| title_full | Nuclear magnetic resonance sensors and methods for chemical sensing in tissue |
| title_fullStr | Nuclear magnetic resonance sensors and methods for chemical sensing in tissue |
| title_full_unstemmed | Nuclear magnetic resonance sensors and methods for chemical sensing in tissue |
| title_short | Nuclear magnetic resonance sensors and methods for chemical sensing in tissue |
| title_sort | nuclear magnetic resonance sensors and methods for chemical sensing in tissue |
| topic | Electrical Engineering and Computer Science. |
| url | http://hdl.handle.net/1721.1/105679 |
| work_keys_str_mv | AT bashyamashvinashvinreddy nuclearmagneticresonancesensorsandmethodsforchemicalsensingintissue |