Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System

Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System

The microbial adaptive immune system CRISPR mediates defense against foreign genetic elements through two classes of RNA-guided nuclease effectors. Class 1 effectors utilize multiprotein complexes, whereas Class 2 effectors rely on single-component effector proteins such as the well-characterized Ca...

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Bibliographic Details
Main Authors: Makarova, Kira S., van der Oost, John, Koonin, Eugene V., Zetsche, Bernd, Gootenberg, Jonathan S, Abudayyeh, Omar Osama, Slaymaker, Ian, Essletzbichler, Patrick, Volz, Sara E., Joung, Julia, Regev, Aviv, Zhang, Feng
Other Authors: Harvard University--MIT Division of Health Sciences and Technology
Format: Article
Language:en_US
Published: Elsevier 2016
Online Access:http://hdl.handle.net/1721.1/105747
https://orcid.org/0000-0002-7979-3220
https://orcid.org/0000-0001-8794-2137
https://orcid.org/0000-0001-6656-5002
https://orcid.org/0000-0001-8567-2049
https://orcid.org/0000-0003-2782-2509

Internet

http://hdl.handle.net/1721.1/105747
https://orcid.org/0000-0002-7979-3220
https://orcid.org/0000-0001-8794-2137
https://orcid.org/0000-0001-6656-5002
https://orcid.org/0000-0001-8567-2049
https://orcid.org/0000-0003-2782-2509

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