The Caenorhabditis elegans Protein FIC-1 Is an AMPylase That Covalently Modifies Heat-Shock 70 Family Proteins, Translation Elongation Factors and Histones

The Caenorhabditis elegans Protein FIC-1 Is an AMPylase That Covalently Modifies Heat-Shock 70 Family Proteins, Translation Elongation Factors and Histones

Protein AMPylation by Fic domain-containing proteins (Fic proteins) is an ancient and conserved post-translational modification of mostly unexplored significance. Here we characterize the Caenorhabditis elegans Fic protein FIC-1 in vitro and in vivo. FIC-1 is an AMPylase that localizes to the nuclea...

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Bibliographic Details
Main Authors: Truttmann, Matthias, Cruz, Victor Emmanuel, Guo, Xuanzong, Engert, Christoph, Schwartz, Thomas, Ploegh, Hidde
Other Authors: Massachusetts Institute of Technology. Computational and Systems Biology Program
Format: Article
Language:en_US
Published: Public Library of Science 2016
Online Access:http://hdl.handle.net/1721.1/105785
https://orcid.org/0000-0001-5338-0973
https://orcid.org/0000-0001-6819-8832
https://orcid.org/0000-0001-8012-1512
https://orcid.org/0000-0002-1090-6071

Internet

http://hdl.handle.net/1721.1/105785
https://orcid.org/0000-0001-5338-0973
https://orcid.org/0000-0001-6819-8832
https://orcid.org/0000-0001-8012-1512
https://orcid.org/0000-0002-1090-6071

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