IDH1 Mutations Alter Citric Acid Cycle Metabolism and Increase Dependence on Oxidative Mitochondrial Metabolism

IDH1 Mutations Alter Citric Acid Cycle Metabolism and Increase Dependence on Oxidative Mitochondrial Metabolism

Oncogenic mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2) occur in several types of cancer, but the metabolic consequences of these genetic changes are not fully understood. In this study, we performed 13C metabolic flux analysis on a panel of isogenic cell lines containing heterozygous IDH1/...

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Bibliographic Details
Main Authors: Grassian, A. R., Parker, S. J., Divakaruni, A. S., Green, C. R., Zhang, X., Slocum, K. L., Pu, M., Lin, F., Vickers, C., Joud-Caldwell, C., Chung, F., Yin, H., Handly, E. D., Straub, C., Growney, J. D., Murphy, A. N., Pagliarini, R., Metallo, C. M., Davidson, Shawn M, Vander Heiden, Matthew G.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: American Association for Cancer Research 2016
Online Access:http://hdl.handle.net/1721.1/105819
https://orcid.org/0000-0002-6702-4192

Internet

http://hdl.handle.net/1721.1/105819
https://orcid.org/0000-0002-6702-4192

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