Human Phosphoglycerate Dehydrogenase Produces the Oncometabolite d-2-Hydroxyglutarate

Human Phosphoglycerate Dehydrogenase Produces the Oncometabolite d-2-Hydroxyglutarate

Human d-3-phosphoglycerate dehydrogenase (PHGDH), the first enzyme in the serine biosynthetic pathway, is genomically amplified in tumors including breast cancer and melanoma. In PHGDH-amplified cancer cells, knockdown of PHGDH is not fully rescued by exogenous serine, suggesting possible additional...

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Bibliographic Details
Main Authors: Teng, Xin, Liu, Ling, Looper, Ryan E., Rabinowitz, Joshua D., Vander Heiden, Matthew G., Mattaini, Katherine Ruth, Fan, Jing,M. Eng.Massachusetts Institute of Technology.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: American Chemical Society (ACS) 2016
Online Access:http://hdl.handle.net/1721.1/105823
https://orcid.org/0000-0002-6702-4192
https://orcid.org/0000-0003-0046-1360

Internet

http://hdl.handle.net/1721.1/105823
https://orcid.org/0000-0002-6702-4192
https://orcid.org/0000-0003-0046-1360

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