Famine versus feast: understanding the metabolism of tumors in vivo
To fuel unregulated proliferation, cancer cells alter metabolism to support macromolecule biosynthesis. Cell culture studies have revealed how different oncogenic mutations and nutrients impact metabolism. Glucose and glutamine are the primary fuels used in vitro; however, recent studies have sugge...
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| Format: | Article |
| Language: | en_US |
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Elsevier
2016
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| Online Access: | http://hdl.handle.net/1721.1/105824 https://orcid.org/0000-0002-6702-4192 https://orcid.org/0000-0002-8607-1787 |
| _version_ | 1826193585627725824 |
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| author | Vander Heiden, Matthew G. Mayers, Jared R. |
| author2 | Harvard University--MIT Division of Health Sciences and Technology |
| author_facet | Harvard University--MIT Division of Health Sciences and Technology Vander Heiden, Matthew G. Mayers, Jared R. |
| author_sort | Vander Heiden, Matthew G. |
| collection | MIT |
| description | To fuel unregulated proliferation, cancer cells alter metabolism to support macromolecule biosynthesis. Cell culture studies have revealed how different oncogenic mutations and nutrients impact metabolism. Glucose and glutamine are the primary fuels used in vitro; however, recent
studies have suggested that utilization of other amino acids as well as lipids and protein can also be important to cancer cells. Early investigations of tumor metabolism are translating these findings to the biology of whole tumors and suggest that additional complexity exists beyond nutrient availability alone in vivo. Whole body metabolism and tumor heterogeneity also influence the metabolism of tumor cells, and successful targeting of metabolism for cancer therapy will require an understanding of tumor metabolism in vivo. |
| first_indexed | 2024-09-23T09:41:27Z |
| format | Article |
| id | mit-1721.1/105824 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T09:41:27Z |
| publishDate | 2016 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/1058242022-09-26T13:10:21Z Famine versus feast: understanding the metabolism of tumors in vivo Vander Heiden, Matthew G. Mayers, Jared R. Harvard University--MIT Division of Health Sciences and Technology Massachusetts Institute of Technology. Department of Biology Koch Institute for Integrative Cancer Research at MIT Vander Heiden, Matthew G. Mayers, Jared R. To fuel unregulated proliferation, cancer cells alter metabolism to support macromolecule biosynthesis. Cell culture studies have revealed how different oncogenic mutations and nutrients impact metabolism. Glucose and glutamine are the primary fuels used in vitro; however, recent studies have suggested that utilization of other amino acids as well as lipids and protein can also be important to cancer cells. Early investigations of tumor metabolism are translating these findings to the biology of whole tumors and suggest that additional complexity exists beyond nutrient availability alone in vivo. Whole body metabolism and tumor heterogeneity also influence the metabolism of tumor cells, and successful targeting of metabolism for cancer therapy will require an understanding of tumor metabolism in vivo. Grant F30 CA183474 Burroughs Wellcome Fund Lustgarten Foundation American Association for Cancer Research National Cancer Institute (U.S.) 2016-12-15T15:01:27Z 2016-12-15T15:01:27Z 2015-01 Article http://purl.org/eprint/type/JournalArticle 09680004 http://hdl.handle.net/1721.1/105824 Mayers, Jared R., and Matthew G. Vander Heiden. “Famine versus Feast: Understanding the Metabolism of Tumors in Vivo.” Trends in Biochemical Sciences 40.3 (2015): 130–140. https://orcid.org/0000-0002-6702-4192 https://orcid.org/0000-0002-8607-1787 en_US http://dx.doi.org/10.1016/j.tibs.2015.01.004 Trends in Biochemical Sciences Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier PMC |
| spellingShingle | Vander Heiden, Matthew G. Mayers, Jared R. Famine versus feast: understanding the metabolism of tumors in vivo |
| title | Famine versus feast: understanding the metabolism of tumors in vivo |
| title_full | Famine versus feast: understanding the metabolism of tumors in vivo |
| title_fullStr | Famine versus feast: understanding the metabolism of tumors in vivo |
| title_full_unstemmed | Famine versus feast: understanding the metabolism of tumors in vivo |
| title_short | Famine versus feast: understanding the metabolism of tumors in vivo |
| title_sort | famine versus feast understanding the metabolism of tumors in vivo |
| url | http://hdl.handle.net/1721.1/105824 https://orcid.org/0000-0002-6702-4192 https://orcid.org/0000-0002-8607-1787 |
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