Lack of Evidence for PKM2 Protein Kinase Activity

The role of pyruvate kinase M2 (PKM2) in cell proliferation is controversial. A unique function of PKM2 proposed to be important for the proliferation of some cancer cells involves the direct activity of this enzyme as a protein kinase; however, a detailed biochemical characterization of this activi...

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Bibliographic Details
Main Authors: Hosios, Aaron Marc, Fiske, Brian Prescott, Gui, Dan Yi, Vander Heiden, Matthew G.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Elsevier 2016
Online Access:http://hdl.handle.net/1721.1/105827
https://orcid.org/0000-0002-7702-5877
https://orcid.org/0000-0003-0130-3428
https://orcid.org/0000-0002-6702-4192