Neighbor-directed histidine N (τ)-alkylation: A route to imidazolium-containing phosphopeptide macrocycles

Our recently discovered, selective, on-resin route to N(τ)-alkylated imidazolium-containing histidine residues affords new strategies for peptide mimetic design. In this, we demonstrate the use of this chemistry to prepare a series of macrocyclic phosphopeptides, in which imidazolium groups serve as...

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Bibliographic Details
Main Authors: Qian, Wen-Jian, Park, Jung-Eun, Lai, Christopher C., Kelley, James A., Lee, Kyung S., Burke, Terrence R., Grant, Robert A, Yaffe, Michael B
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Wiley Blackwell 2016
Online Access:http://hdl.handle.net/1721.1/105840
https://orcid.org/0000-0002-9547-3251