Mono-anionic phosphopeptides produced by unexpected histidine alkylation exhibit high plk1 polo-box domain-binding affinities and enhanced antiproliferative effects in hela cells

Mono-anionic phosphopeptides produced by unexpected histidine alkylation exhibit high plk1 polo-box domain-binding affinities and enhanced antiproliferative effects in hela cells

Binding of polo-like kinase 1 (Plk1) polo-box domains (PBDs) to phosphothreonine (pThr)/phosphoserine (pSer)-containing sequences is critical for the proper function of Plk1. Although high-affinity synthetic pThr-containing peptides provide starting points for developing PBD-directed inhibitors, to...

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Bibliographic Details
Main Authors: Qian, Wen-Jian, Park, Jung-Eun, Lai, Christopher C., Kelley, James A., Park, Suk-Youl, Lee, Ki Won, Lee, Kyung S., Burke, Terrence R., Lim, Daniel Cham-Chin, Yaffe, Michael B
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Wiley Blackwell 2016
Online Access:http://hdl.handle.net/1721.1/105869
https://orcid.org/0000-0002-9547-3251

Internet

http://hdl.handle.net/1721.1/105869
https://orcid.org/0000-0002-9547-3251

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