Intraperitoneal delivery of paclitaxel by poly(ether-anhydride) microspheres effectively suppresses tumor growth in a murine metastatic ovarian cancer model
Intraperitoneal (IP) chemotherapy is more effective than systemic chemotherapy for treating advanced ovarian cancer, but is typically associated with severe complications due to high dose, frequent administration schedule, and use of non-biocompatible excipients/delivery vehicles. Here, we developed...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Springer US
2016
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| Online Access: | http://hdl.handle.net/1721.1/106169 |
| _version_ | 1826196385832108032 |
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| author | Wood, Joseph Wang, Ying-Ying Zeng, Qi Simons, Brian W Fu, Jie Chuang, Chi-Mu Lai, Samuel K Wu, T.-C. Hung, Chien-Fu Hanes, Justin Simons, Brian W. Lai, Samuel K. Tang, Benjamin C. Yang, Ming, S.M. Massachusetts Institute of Technology Yu, Tao, Ph. D. Massachusetts Institute of Technology |
| author2 | Koch Institute for Integrative Cancer Research at MIT |
| author_facet | Koch Institute for Integrative Cancer Research at MIT Wood, Joseph Wang, Ying-Ying Zeng, Qi Simons, Brian W Fu, Jie Chuang, Chi-Mu Lai, Samuel K Wu, T.-C. Hung, Chien-Fu Hanes, Justin Simons, Brian W. Lai, Samuel K. Tang, Benjamin C. Yang, Ming, S.M. Massachusetts Institute of Technology Yu, Tao, Ph. D. Massachusetts Institute of Technology |
| author_sort | Wood, Joseph |
| collection | MIT |
| description | Intraperitoneal (IP) chemotherapy is more effective than systemic chemotherapy for treating advanced ovarian cancer, but is typically associated with severe complications due to high dose, frequent administration schedule, and use of non-biocompatible excipients/delivery vehicles. Here, we developed paclitaxel (PTX)-loaded microspheres composed of di-block copolymers of poly(ethylene glycol) and poly(sebacic acid) (PEG-PSA) for safe and sustained IP chemotherapy. PEG-PSA microspheres provided efficient loading (∼13 % w/w) and prolonged release (∼13 days) of PTX. In a murine ovarian cancer model, a single dose of IP PTX/PEG-PSA particles effectively suppressed tumor growth for more than 40 days and extended the median survival time to 75 days compared to treatments with Taxol® (47 days) or IP placebo particles (34 days). IP PTX/PEG-PSA was well tolerated with only minimal to mild inflammation. Our findings support PTX/PEG-PSA microspheres as a promising drug delivery platform for IP therapy of ovarian cancer and potentially other metastatic peritoneal cancers. |
| first_indexed | 2024-09-23T10:26:02Z |
| format | Article |
| id | mit-1721.1/106169 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T10:26:02Z |
| publishDate | 2016 |
| publisher | Springer US |
| record_format | dspace |
| spelling | mit-1721.1/1061692022-09-26T17:53:42Z Intraperitoneal delivery of paclitaxel by poly(ether-anhydride) microspheres effectively suppresses tumor growth in a murine metastatic ovarian cancer model Wood, Joseph Wang, Ying-Ying Zeng, Qi Simons, Brian W Fu, Jie Chuang, Chi-Mu Lai, Samuel K Wu, T.-C. Hung, Chien-Fu Hanes, Justin Simons, Brian W. Lai, Samuel K. Tang, Benjamin C. Yang, Ming, S.M. Massachusetts Institute of Technology Yu, Tao, Ph. D. Massachusetts Institute of Technology Koch Institute for Integrative Cancer Research at MIT Tang, Benjamin C. Intraperitoneal (IP) chemotherapy is more effective than systemic chemotherapy for treating advanced ovarian cancer, but is typically associated with severe complications due to high dose, frequent administration schedule, and use of non-biocompatible excipients/delivery vehicles. Here, we developed paclitaxel (PTX)-loaded microspheres composed of di-block copolymers of poly(ethylene glycol) and poly(sebacic acid) (PEG-PSA) for safe and sustained IP chemotherapy. PEG-PSA microspheres provided efficient loading (∼13 % w/w) and prolonged release (∼13 days) of PTX. In a murine ovarian cancer model, a single dose of IP PTX/PEG-PSA particles effectively suppressed tumor growth for more than 40 days and extended the median survival time to 75 days compared to treatments with Taxol® (47 days) or IP placebo particles (34 days). IP PTX/PEG-PSA was well tolerated with only minimal to mild inflammation. Our findings support PTX/PEG-PSA microspheres as a promising drug delivery platform for IP therapy of ovarian cancer and potentially other metastatic peritoneal cancers. 2016-12-28T20:57:42Z 2016-12-28T20:57:42Z 2014-01 2016-08-18T15:46:36Z Article http://purl.org/eprint/type/JournalArticle 2190-393X 2190-3948 http://hdl.handle.net/1721.1/106169 Yang, Ming et al. “Intraperitoneal Delivery of Paclitaxel by Poly(ether-Anhydride) Microspheres Effectively Suppresses Tumor Growth in a Murine Metastatic Ovarian Cancer Model.” Drug Delivery and Translational Research 4.2 (2014): 203–209. en http://dx.doi.org/10.1007/s13346-013-0190-7 Drug Delivery and Translational Research Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. Controlled Release Society application/pdf Springer US Springer US |
| spellingShingle | Wood, Joseph Wang, Ying-Ying Zeng, Qi Simons, Brian W Fu, Jie Chuang, Chi-Mu Lai, Samuel K Wu, T.-C. Hung, Chien-Fu Hanes, Justin Simons, Brian W. Lai, Samuel K. Tang, Benjamin C. Yang, Ming, S.M. Massachusetts Institute of Technology Yu, Tao, Ph. D. Massachusetts Institute of Technology Intraperitoneal delivery of paclitaxel by poly(ether-anhydride) microspheres effectively suppresses tumor growth in a murine metastatic ovarian cancer model |
| title | Intraperitoneal delivery of paclitaxel by poly(ether-anhydride) microspheres effectively suppresses tumor growth in a murine metastatic ovarian cancer model |
| title_full | Intraperitoneal delivery of paclitaxel by poly(ether-anhydride) microspheres effectively suppresses tumor growth in a murine metastatic ovarian cancer model |
| title_fullStr | Intraperitoneal delivery of paclitaxel by poly(ether-anhydride) microspheres effectively suppresses tumor growth in a murine metastatic ovarian cancer model |
| title_full_unstemmed | Intraperitoneal delivery of paclitaxel by poly(ether-anhydride) microspheres effectively suppresses tumor growth in a murine metastatic ovarian cancer model |
| title_short | Intraperitoneal delivery of paclitaxel by poly(ether-anhydride) microspheres effectively suppresses tumor growth in a murine metastatic ovarian cancer model |
| title_sort | intraperitoneal delivery of paclitaxel by poly ether anhydride microspheres effectively suppresses tumor growth in a murine metastatic ovarian cancer model |
| url | http://hdl.handle.net/1721.1/106169 |
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