Identification and characterization of essential genes in the human genome

Identification and characterization of essential genes in the human genome

Large-scale genetic analysis of lethal phenotypes has elucidated the molecular underpinnings of many biological processes. Using the bacterial clustered regularly interspaced short palindromic repeats (CRISPR) system, we constructed a genome-wide single-guide RNA (sgRNA) library to screen for genes...

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Bibliographic Details
Main Authors: Hughes, N. W., Wang, Tim, Birsoy, Kivanc, Krupczak, Kevin M., Post, Yorick, Lander, Eric Steven, Sabatini, David, Wei, Jenny J.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: American Association for the Advancement of Science (AAAS) 2017
Online Access:http://hdl.handle.net/1721.1/106204
https://orcid.org/0000-0002-4227-5163
https://orcid.org/0000-0002-1446-7256

Internet

http://hdl.handle.net/1721.1/106204
https://orcid.org/0000-0002-4227-5163
https://orcid.org/0000-0002-1446-7256

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