The Dynamics of Eukaryotic Replication Initiation: Origin Specificity, Licensing, and Firing at the Single-Molecule Level

The Dynamics of Eukaryotic Replication Initiation: Origin Specificity, Licensing, and Firing at the Single-Molecule Level

Eukaryotic replication initiation is highly regulated and dynamic. It begins with the origin recognition complex (ORC) binding DNA sites called origins of replication. ORC, together with Cdc6 and Cdt1, mediate pre-replicative complex (pre-RC) assembly by loading a double hexamer of Mcm2–7: the core...

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Bibliographic Details
Main Authors: Duzdevich, Daniel, Ticau, Simina, Greene, Eric C., Warner, Megan Dobbins, Ivica, Nikola, Bell, Stephen P
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Elsevier 2017
Online Access:http://hdl.handle.net/1721.1/106210
https://orcid.org/0000-0003-1736-6343
https://orcid.org/0000-0002-0124-0087
https://orcid.org/0000-0002-2876-610X

Internet

http://hdl.handle.net/1721.1/106210
https://orcid.org/0000-0003-1736-6343
https://orcid.org/0000-0002-0124-0087
https://orcid.org/0000-0002-2876-610X

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