Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining

Methods to introduce targeted double-strand breaks (DSBs) into DNA enable precise genome editing by increasing the rate at which externally supplied DNA fragments are incorporated into the genome through homologous recombination. The efficiency of these methods is limited by nonhomologous end joinin...

詳細記述

書誌詳細
主要な著者: Maruyama, Takeshi, Dougan, Stephanie K, Truttmann, Matthias C, Bilate, Angelina M, Ingram, Jessica R, Ploegh, Hidde
その他の著者: Massachusetts Institute of Technology. Department of Biology
フォーマット: 論文
言語:en_US
出版事項: Nature Publishing Group 2017
オンライン・アクセス:http://hdl.handle.net/1721.1/106223
https://orcid.org/0000-0002-1090-6071