Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining
Methods to introduce targeted double-strand breaks (DSBs) into DNA enable precise genome editing by increasing the rate at which externally supplied DNA fragments are incorporated into the genome through homologous recombination. The efficiency of these methods is limited by nonhomologous end joinin...
| Autori principali: | , , , , , |
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| Altri autori: | |
| Natura: | Articolo |
| Lingua: | en_US |
| Pubblicazione: |
Nature Publishing Group
2017
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| Accesso online: | http://hdl.handle.net/1721.1/106223 https://orcid.org/0000-0002-1090-6071 |