Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining

Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining

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Methods to introduce targeted double-strand breaks (DSBs) into DNA enable precise genome editing by increasing the rate at which externally supplied DNA fragments are incorporated into the genome through homologous recombination. The efficiency of these methods is limited by nonhomologous end joinin...

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Bibliografiska uppgifter
Huvudupphovsmän: Maruyama, Takeshi, Dougan, Stephanie K, Truttmann, Matthias C, Bilate, Angelina M, Ingram, Jessica R, Ploegh, Hidde
Övriga upphovsmän: Massachusetts Institute of Technology. Department of Biology
Materialtyp: Artikel
Språk:en_US
Publicerad: Nature Publishing Group 2017
Länkar:http://hdl.handle.net/1721.1/106223
https://orcid.org/0000-0002-1090-6071

Internet

http://hdl.handle.net/1721.1/106223
https://orcid.org/0000-0002-1090-6071

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