Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer’s Disease Phenotypes

Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer’s Disease Phenotypes

The dismal success rate of clinical trials for Alzheimer’s disease (AD) motivates us to develop model systems of AD pathology that have higher predictive validity. The advent of induced pluripotent stem cells (iPSCs) allows us to model pathology and study disease mechanisms directly in human neural...

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Bibliographic Details
Main Authors: Raja, Waseem K, Mungenast, Alison, Lin, Yuan-Ta, Ko, Tak, Abdurrob, Fatema, Seo, Jinsoo, Tsai, Li-Huei
Other Authors: Picower Institute for Learning and Memory
Format: Article
Language:en_US
Published: Public Library of Science 2017
Online Access:http://hdl.handle.net/1721.1/106315
https://orcid.org/0000-0002-5452-2352
https://orcid.org/0000-0002-2461-1135
https://orcid.org/0000-0003-1262-0592

Internet

http://hdl.handle.net/1721.1/106315
https://orcid.org/0000-0002-5452-2352
https://orcid.org/0000-0002-2461-1135
https://orcid.org/0000-0003-1262-0592

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