Overexpression of CupB5 activates alginate overproduction in Pseudomonas aeruginosa by a novel AlgW-dependent mechanism

In Pseudomonas aeruginosa, alginate overproduction, also known as mucoidy, is negatively regulated by the transmembrane protein MucA, which sequesters the alternative sigma factor AlgU. MucA is degraded via a proteolysis pathway that frees AlgU from sequestration, activating alginate biosynthesis. I...

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Bibliographic Details
Main Authors: Yin, Yeshi, Withers, T. Ryan, Wang, Xin, Yu, Hongwei D., de Regt, Anna Katherine, Baker, Tania, Sauer, Robert T.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Wiley Blackwell 2017
Online Access:http://hdl.handle.net/1721.1/106340
https://orcid.org/0000-0002-1719-5399