A Conserved Activation Cluster Is Required for Allosteric Communication in HtrA-Family Proteases

A Conserved Activation Cluster Is Required for Allosteric Communication in HtrA-Family Proteases

In E. coli, outer-membrane stress causes a transcriptional response through a signaling cascade initiated by DegS cleavage of a transmembrane anti-sigma factor. Each subunit of DegS, an HtrAfamily protease, contains a protease domain and a PDZ domain. The trimeric protease domain is autoinhibited b...

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Bibliographic Details
Main Authors: de Regt, Anna K., Kim, Seokhee, Sohn, Jungsan, Grant, Robert A., Baker, Tania A.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Elsevier 2017
Online Access:http://hdl.handle.net/1721.1/106341

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http://hdl.handle.net/1721.1/106341

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